Structure of Flavin Adducts with Acetylenic Substrates. Chemistry of Monoamine Oxidase and Lactate Oxidase Inhibition
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چکیده
منابع مشابه
Inhibition of monoamine oxidase by stilbenes from Rheum palmatum
Seven stilbenes and one catechin were bioactivity-guidedly isolated from the rhizomes of Rheum palmatem. Their structures were identified as piceatannol(1), resveratrol(2), piceid(3), rhapontigenin(4), piceatannol-3'-O-β-D-glucopyranoside(5), rhaponticin(6), catechin(7) and desoxyrhapontigenin(8). Anti-monoamine oxidase (MAO) activities of compounds 1–8 were tested. Compounds 1 and 8 showed sig...
متن کاملInhibition of monoamine oxidase by stilbenes from Rheum palmatum
Seven stilbenes and one catechin were bioactivity-guidedly isolated from the rhizomes of Rheum palmatem. Their structures were identified as piceatannol(1), resveratrol(2), piceid(3), rhapontigenin(4), piceatannol-3'-O-β-D-glucopyranoside(5), rhaponticin(6), catechin(7) and desoxyrhapontigenin(8). Anti-monoamine oxidase (MAO) activities of compounds 1–8 were tested. Compounds 1 and 8 showed sig...
متن کاملCovalent adducts of lactate oxidase. Photochemical formation and structure identification.
Lactate oxidase forms tight complexes with a variety of mono- and dicarboxylic acids. Most of these undergo facile photoreactions involving decarboxylation of the carboxylic acid and formation of covalent adducts at position N(5) of the flavin, characterized by absorption maxima from 325 to 365 nm and fluorescence emission in the range 440 to 490 nm. The properties of the adducts are strongly d...
متن کاملStabilization of Lactate Oxidase Flavin Anion Radical
The red-colored flavin anion radical of lactate oxidase was formed by photochemical reduction. The radical was found to be reoxidized readily by molecular oxygen, with a rate constant of 4 X lo5 M "I min" at pH 7.0, 25°C. On mixing the radical under anaerobic conditions with pyruvate, a change in spectrum typical of charge transfer interaction was found. The complex was composed of 1 eq of pyru...
متن کاملMonoamine oxidase inhibition.
Introduction The discovery that inhibitors of monoamine oxidase (EC 1.4.3.4.; MAO) are antidepressants (see [ l ] for a review) has resulted in the synthesis of large numbers of inhibitors, several of which have proved to be valuable in clinical use. Such work was given added impetus when it was recognized that there are two monoamine oxidases in most mammalian tissues, MAO-A and MAO-B, with di...
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ژورنال
عنوان ژورنال: European Journal of Biochemistry
سال: 1976
ISSN: 0014-2956,1432-1033
DOI: 10.1111/j.1432-1033.1976.tb10223.x